Just like human beings, if you don't get your Sims to the toilet in time, they wet themselves. This reminds me a lot of that movie-turned-TV show Limitless, so you can use this mod to live out your Bradley Cooper fantasies. The Awakened Mind Trait mod created by alan650 on Mod The Sims gives your Sim an 'advanced' brain that makes it so they rarely need sleep, advance their mental skills quickly and never experience discomfort, which is about as far from being human as you can get. If you want your Sim to act like the Energizer Bunny, there's a mod for that.